General Cell Lines and Cell Cultures
XenoTech,LLC Pooled IGS Sprague-Dawley rat liver microsomes, female, 0.5 ML at 20 ME/ML (10 ME)
Pooled IGS Sprague-Dawley rat liver microsomes, female, 0.5 ML at 20 ME/ML (10 ME)
HORIZON DISCOVERY BIOSCIENCES LIMITED MGC HUMAN IFNGR1 SEQUENCE-VERI
NC2873009 MGC HUMAN IFNGR1 SEQUENCE-VERI
Cell Applications Inc Pre-Screened Cryopreserved Dermal Microvascular Endothelial Cell Total Kit
Pre-Screened Cryopreserved Dermal Microvascular Endothelial Cell Total Kit:(S100-05a) Pre-Screened Cryopreserved (CADMEC), 1 vial, adult(112-500) Dermal Microvascular Endothelial Cells Growth Media, 500ml(090K) Subculture Reagent Kit(121-25-02) Extracellular Matrix, 2ml(123-100) Attachment Factor
Eurofins Discoverx PathHunter CHO-K1 GPR120S (Short Isoform) β-Arrestin-1 Cell Line, 2 vials. (93-0978C2)
The PathHunter GPR120S (ARR1) cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. free fatty acids) based activation of GPR120S GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR120S and EA-tagged β-Arrestin-1. Activation of GPR120S stimulates the recruitment of β-Arrestin-1 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter U2OS HTR5A β-Arrestin Cell Line, 2 vials. (93-0700C3)
The PathHunter HTR5A cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. serotonin) based activation of HTR5A GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged HTR5A and EA-tagged β-Arrestin-2. Activation of HTR5A stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter U2OS SREBP2 Nuclear Translocation Cell Line, 2 vials. (93-0830C3)
The PathHunter U2OS SREBP2 Nuclear Translocation Cell Line is a stable, engineered cell line for use in studying drug candidates affecting the cholesterol biosynthesis pathway. This cell line enables assessment of ligand (e.g. 5'-UMP) based pathway activation via detection of resulting SREBP2 nuclear translocation. This product uses EFC technology. The included cell line overexpresses ProLabel-tagged SREBP2 and nuclear localized EA. Upon pathway activation, induced nuclear translocation of SREBP2 leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/pathways.
Eurofins Discoverx PathHunter U2OS IL23R/IL12RB1 Dimerization Cell Line, 2 vials. (93-1007C3)
The PathHunter IL23R/IL12RB1 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-23) induced dimerization of IL23R/IL12RB1 receptors. This product uses EFC technology. The cell line included overexpresses IL23R target protein fused to PK alongside IL12RB1 target protein fused to EA. Upon ligand-induced dimerization of IL23R/IL12RB1, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/interleukins.
Eurofins Discoverx PathHunter U2OS IL20RA/IL10RB Dimerization Cell Line, 2 vials. (93-1020C3)
The PathHunter IL20RA/IL10RB Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-26) induced dimerization of IL20RA/IL10RB receptors. This product uses EFC technology. The cell line included overexpresses IL20RA target protein fused to PK alongside IL10RB target protein fused to EA. Upon ligand-induced dimerization of IL20RA/IL10RB, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/interleukins.
Eurofins Discoverx PathHunter U2OS IL4R/IL13RA1 Dimerization Cell Line, 2 vials. (93-1000C3)
The PathHunter IL4R/IL13RA1 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-13) induced dimerization of IL4R/IL13RA1 receptors. This product uses EFC technology. The cell line included overexpresses IL4R target protein fused to PK alongside IL13RA1 target protein fused to EA. Upon ligand-induced dimerization of IL4R/IL13RA1, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/interleukins.
Eurofins Discoverx PathHunter GPR35 Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0968C3)
The PathHunter GPR35 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of GPR35 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged GPR35. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting GPR35-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx cAMP Hunter CHO-K1 CCR1 Gi Cell Line, 2 vials. (95-0066C2)
The cAMP Hunter CCR1 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CCL3) based activation of CCR1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type CCR1, a naturally Gi/Go coupled GPCR. Upon activation of CCR1, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter U2OS BMPR1A/ACVR2A Dimerization Cell Line, 2 vials. (93-1037C3)
The PathHunter BMPR1A/ACVR2A Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. BMP-4) induced dimerization of BMPR1A/ACVR2A receptors. This product uses EFC technology. The cell line included overexpresses BMPR1A target protein fused to PK alongside ACVR2A target protein fused to EA. Upon ligand-induced dimerization of BMPR1A/ACVR2A, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx PathHunter P2RY1 Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0967C3)
The PathHunter P2RY1 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of P2RY1 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged P2RY1. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting P2RY1-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Cell Applications Inc Proliferating Umbilical Vein Endothelial Cells (HUVEC), Fetal
Proliferating Umbilical Vein Endothelial Cells (HUVEC), Fetal
Cell Applications Inc Proliferating Coronary Artery Endothelial Cells (HCAEC), Adult
Proliferating Coronary Artery Endothelial Cells (HCAEC), Adult